AUTHORS Ignacio Casares/ Master en Ingeniería Industrial/ Universidad Carlos III de Madrid
SUPERVISORS Eduardo Lage / PhD / PlenOptika Europe
Carlos Santiago Hernandez Torres / MS/ PlenOptika Europe
Miguel Marco Esteban/ PhD/ UC3M
TYPE Master’s Thesis
ABSTRACT ABSTRACT

Motivation: Uncorrected refractive errors are the main cause of visual impairment worldwide. Hundreds of millions of people suffer from uncorrected refractive errors. The great majority of this population live in low resource settings. This, however, has been proved to not be caused by difficult access to treatment, as eyeglasses are a very cost-effective treatment and the majority of all visual impairment can be treated in some way, but due to a diagnosis barrier. This is to say, there are very few professionals which can correctly diagnose these errors.
This is where the QuickSee comes in. PlenOptika Inc. (USA), in collaboration with the ‘Universidad Autónoma de Madrid’, developed the QuickSee as a solution to the global health problem caused by uncorrected refractive errors. The QuickSee is a low-cost autorefractor designed with simplicity in mind to allow personnel with minimal training to obtain an eyeglass prescription. In a few seconds, it can accurately measure existing refractive errors, thus facilitating eye care access to lower resource settings and closing the diagnosis gap.
Problem: The QuickSee is currently being fully commercialized throughout the globe. It has proved to be very useful in easing access to eyecare, as well as streamlining the process to achieve an eyeglass prescription. However, feedback received from users have shown that the refraction process may be further ‘automated’ or optimized. If subjective refraction were to be incorporated in the same step as objective refraction.

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AUTHORS Jesus Poderoso / Ingeniería Informática / Universidad Autónoma de Madrid
SUPERVISORS Carlos S. Hernández / MsC / PlenOptika Europe
TYPE Bachelor Thesis
ABSTRACT ABSTRACT

Refractive errors are very common eye disorders in which the eye cannot clearly focus on images. If they are not diagnosed in time, especially during childhood, they may result in severe visual impairment and even blindness. Refractive errors can be corrected simply by wearing glasses, an effective and inexpensive remedy whose cost does not exceed $5 in developing countries. Even so, refractive errors are currently one of the major global health problems. The main cause of this situation is the shortage of eye care professionals and automated equipment capable of prescribing glasses. PlenOptika proposes as a solution the QuickSee, a low cost and easy to use autorefractor. This device improves the efficiency and scope of eyecare professionals to prescribe glasses, while enabling people with minimal training in refractive techniques such as nurses, technicians or even non-healthcare personnel to carry out measurements of refractive errors quickly and reliably.

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AUTHORS / CAREER / CENTER Marcos Rubio Rubio / Master in Multimedia Communications / Universidad Carlos III de Madrid
SUPERVISORS Eduardo Lage / PhD / Universidad Autonoma de Madrid
TYPE Master’s Thesis
ABSTRACT ABSTRACT
The clinical accuracy of objective refraction instruments has improved over the last decade thanks to the implementation of faster, more accurate and easier to operate autorefractors. Despite these improvements, subjective refraction (SR) remains the gold standard for prescribing eyeglasses because, even though it takes much longer than an objective reading, allows taking into account the visual preferences of the patient and iteratively improving their visual acuity (VA). This work proposes an automatic classification system which has been designed to predict clinically relevant disagreements (≥0.75 D in Spherical Equivalent (SE)) between a novel dynamic wavefront aberrometer, the QuickSee Flip (QSf), and subjective refraction.

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AUTHORS / CAREER / CENTER Andrea Gil Ruiz/ Biomedical Engineering / Universidad Carlos III de Madrid
SUPERVISORS Eduardo Lage / PhD / Universidad Autonoma de Madrid

Marcos Rubio Rubio

TYPE Bachelor Thesis
ABSTRACT Motivation: Uncorrected refractive errors affect more than one billion people worldwide because of the limited access to eye care in low-resource settings. Inaccessibility to an eyeglass prescription in developing countries is mainly caused by the shortage of qualified professionals. Our research group in Universidad Autónoma de Madrid, together with the company PlenOptika Inc (USA) introduced a novel handheld open-view autorefractor called QuickSee (QS). The device uses a wavefront sensing approach, avoiding expensive components and it is able to accurately provide eyeglass prescriptions in only 10 seconds. Its ease of use allows minimally-trained personnel to perform refraction. This works explores the possibility of using complete dynamic wavefront information (low- and high-order aberrations and time) to further improve the accuracy of the device and expand its capabilities.

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AUTHORS / CAREER / CENTER Ignacio Casares / Industrial technologies Engineering / Universidad Carlos III de Madrid
SUPERVISOR Eduardo Lage, PhD, Universidad Autonoma de Madrid
TYPE Bachelor Thesis
ABSTRACT Motivation: Uncorrected refractive errors are the main cause of visual
impairment worldwide. Hundreds of millions of people suffer from uncorrected
refractive errors. The grand majority of this population live in low-income
settings. This is not caused because of difficult access to treatment, as
eyeglasses are a very cost-effective treatment and the majority of all visual
impairment can be treated in some way, but due to a diagnosis barrier. This is
to say, there are very few professionals which can correctly diagnose these
errors.
This is where the QuickSee comes in. PlenOptika Inc. (USA), in collaboration
with the ‘Universidad Autónoma de Madrid’, developed the QuickSee as a
solution to the global health problem caused by uncorrected refractive errors.
The QuickSee is a low-cost autorefractor designed with simplicity in mind to
allow personnel with minimal training to obtain an eyeglass prescription. In a
few seconds, it can accurately measure existing refractive errors

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AUTHORS / CAREER / CENTER  Marcos Rubio/ Biomedical Engineering / Universidad Carlos III de Madrid
SUPERVISOR Eduardo Lage, PhD, Universidad Autonoma de Madrid
TYPE Bachelor Thesis
ABSTRACT Motivation: Millions of people suffer from uncorrected poor vision, directly
affecting their daily lives and efficiency at work. This problem accentuates in
developing countries such as China or India, where the access to eye-care is
highly restricted mainly due to the lack of qualified professionals to provide
eyeglasses prescriptions. During the last years our research group in Universidad
Autónoma de Madrid, together with the company Plenoptika Inc (USA) has been
developing the QuickSee: a hand-held and low-cost autorefractor able to obtain
accurate eyeglass prescriptions in a few seconds. The device is extremely easy-
to-use which allows minimally-trained personnel to perform reliable refraction.

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AUTHORS / CAREER / CENTER Enrique Seco Meseguer / Medicine / Universidad Autonoma de Madrid
SUPERVISOR Eduardo Lage, PhD, Universidad Autonoma de Madrid

Pablo Perez-Merino, OD, PhD, Fundacion Jimenez Diaz

TYPE Bachelor Thesis
ABSTRACT Objective: To evaluate the performance of a new low-cost handheld autorefractor design,
the “e-see”, in measuring refractive errors of the eye.

Methods: The e-see is a portable and easy-to-use device for measuring refractive
errors of the eye. It is based on a new wavefront sensor concept in which expensive
components are not used. A study with 57 subjects was performed in order to compare
the eyeglasses prescriptions provided by the new device and standard clinical procedures
(objective refraction using autorefractometer + subjective refraction). Visual Acuity (VA)
was measured for prescriptions provided by each method. This study analyzes the
differences in refraction measurements between the QuickSee, a commercial
autorefractometer and subjective refraction (gold standard), as well as the VA obtained
by each method.

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AUTHORS / CAREER / CENTER Carlos S. Hernandez / Biomedical Engineering / Universidad Carlos III de Madrid
SUPERVISOR Eduardo Lage, PhD, Universidad Autonoma de Madrid
TYPE Bachelor Thesis
ABSTRACT Motivation: A major part of global population suffers poor vision that can be easily
corrected with eyeglasses. Uncorrected refractive errors can lead to severe visual
impairment and even blindness. The problem is that trained eye care professionals or
automated devices that prescribe eyeglasses are not easily available.

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AUTHORS Ignacio Salinas / Ingeniería Informática / Universidad Autónoma de Madrid
SUPERVISORS Eduardo Lage / PhD / PlenOptika Europe
TYPE Bachelor Thesis
ABSTRACT ABSTRACT

This Bachelor Thesis presents the development of a calibration system for a visual simulation device: the SimVis. This system prescribes multifocal lenses allowing patients to know if they adapt correctly to their needs before surgical implantation. To approach the project, the functionality of the calibration system has been divided into three main modules: camera, communication, and image processing, which are finally integrated into a main program. In addition, a calibration cradle prototype has been built to perform verification and validation tests.

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AUTHORS / CAREER / CENTER Jaume Fabregat Marques / Ingeniería Electrónica Industrial y Automática / Universidad Carlos III de Madrid
SUPERVISORS Eduardo Lage / PhD / Universidad Autonoma de Madrid
TYPE Bachelor Thesis
ABSTRACT ABSTRACT

Motivation: Worldwide, it is estimated that more than 1 billion people do not have the eyeglasses they need. This problem is especially prevalent in developing countries due to the lack of an appropriate infrastructure for eyecare deployment and eyecare professionals capable of providing eyeglass prescriptions. The procedure for obtaining these prescriptions consist of using an objective measurement of the refractive power of the eye, which is usually very accurate but can fail in several cases, followed by a subjective refinement which is performed by an eyecare professional based on the feedback of the patient. If the initial objective measurement is not accurate, it can greatly complicate the procedure increasing the time required to refract the patient and thus the bandwidth of the eyecare professionals.

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AUTHORS / CAREER / CENTER Miguel Piró Cristobal/ Biomedical Engineering / Universidad Carlos III de Madrid
SUPERVISORS Eduardo Lage / PhD / Universidad Autonoma de Madrid

Carlos Hernandez Torres

TYPE Bachelor Thesis
ABSTRACT Motivation: A high percentage of the global population suffers from poor vision which can be easily corrected by the prescription of eyeglasses. Refractive errors if not corrected can end in severe or total vision impairment. The main restrain for the use of corrective measures is the lack of eye care professional and/or devices operated by minimally trained personnel which are capable of providing accurate eyeglasses prescriptions.

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AUTHORS / CAREER / CENTER David Garrido/ Biomedical Engineering / Universidad Carlos III de Madrid
SUPERVISOR Eduardo Lage, PhD, Universidad Autonoma de Madrid
TYPE Bachelor Thesis
ABSTRACT Efficient treatment of complex diseases is directly dependent on the ability of the patient to respond to a
given therapy. Multiplexed Positron Emission Tomography (mPET) is arising as a new enabling
technology to provide reliable measurements of several physiological parameters at once. The moinitoring
of these factors hold the potential to provide a more comprehensive view of disorders, simplifying in this
way a tailored therapy selection.

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AUTHORS / CAREER / CENTER Carlos S. Hernandez / Master in Big Data Analytics / Universidad Carlos III de Madrid
SUPERVISOR Eduardo Lage, PhD, Universidad Autonoma de Madrid
TYPE Master Thesis
ABSTRACT Motivation: A large percentage of world population suffers poor vision that can be
easily corrected with eyeglasses. These vision problems are especially problematic in
low-resource settings like China or India where trained eye care professionals or
automated devices that prescribe eyeglasses are not readily available. Uncorrected
refractive errors can lead to severe visual impairment and even blindness if not
properly treated.

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AUTHORS / CAREER / CENTER Yassine Marrackchi/ Biomedical Engineering / Universidad Carlos III de Madrid
SUPERVISOR Eduardo Lage, PhD, Universidad Autonoma de Madrid
TYPE Bachelor Thesis
ABSTRACT Late presbyopia and cataracts are the most common age-related problems that affect
human vision. Although they are two different conditions, they share a common
denominator: the crystalline lens. In the case of presbyopia, the accommodation ability
is gradually lost deteriorating near vision, in the case of cataracts, the perfect
transparency of the lens is lost producing a blurred vision.

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AUTHORS / CAREER / CENTER David Nevares / Biomedical Engineering / Universidad Carlos III de Madrid
SUPERVISOR Eduardo Lage, PhD, Universidad Autonoma de Madrid
TYPE Bachelor Thesis
ABSTRACT Purpose: To compare the visual acuity (VA) resulting from eyeglasses prescribed by a novel autorefractor and by subjective refraction.

Methods: A total of 81 eyes from 42 patients (mean age 38 ± 13yrs, ametropia range -6.25 to +4.5D spherical equivalent power (SE)) were refracted and their VA tested in

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