Year: 2020

A new study published in PLoS ONE, “Assessment of the QuickSee wavefront autorefractor for characterizing refractive errors in school-age children,” finds QuickSee ideally suited to refracting children in school screenings and public health outreach. 

The study, conducted at the Ophthalmology Department of Fundación Jiménez Díaz Hospital included 123 children with moderate refractive error, with and without cycloplegia. Researchers compared QuickSee’s results favorably with those of a top table-mounted autorefractor. 

The authors concluded, “the high-level of agreement between QuickSee and subjective refraction, as well as the resulting VA achieved by the patients in both study groups, suggest that the device would serve as a useful autorefraction tool for pediatric populations. Furthermore, the device’s robust screening metrics, along with its ease of use and handheld form factor, support its use as a pediatric vision screening tool.”

PlenOptika website News

AUTHORS Ignacio Casares/ Master en Ingeniería Industrial/ Universidad Carlos III de Madrid
SUPERVISORS Eduardo Lage / PhD / PlenOptika Europe
Carlos Santiago Hernandez Torres / MS/ PlenOptika Europe
Miguel Marco Esteban/ PhD/ UC3M
TYPE Master’s Thesis
ABSTRACT ABSTRACT

Motivation: Uncorrected refractive errors are the main cause of visual impairment worldwide. Hundreds of millions of people suffer from uncorrected refractive errors. The great majority of this population live in low resource settings. This, however, has been proved to not be caused by difficult access to treatment, as eyeglasses are a very cost-effective treatment and the majority of all visual impairment can be treated in some way, but due to a diagnosis barrier. This is to say, there are very few professionals which can correctly diagnose these errors.
This is where the QuickSee comes in. PlenOptika Inc. (USA), in collaboration with the ‘Universidad Autónoma de Madrid’, developed the QuickSee as a solution to the global health problem caused by uncorrected refractive errors. The QuickSee is a low-cost autorefractor designed with simplicity in mind to allow personnel with minimal training to obtain an eyeglass prescription. In a few seconds, it can accurately measure existing refractive errors, thus facilitating eye care access to lower resource settings and closing the diagnosis gap.
Problem: The QuickSee is currently being fully commercialized throughout the globe. It has proved to be very useful in easing access to eyecare, as well as streamlining the process to achieve an eyeglass prescription. However, feedback received from users have shown that the refraction process may be further ‘automated’ or optimized. If subjective refraction were to be incorporated in the same step as objective refraction.

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The Silmo d’Or is a prestigious award which rewards creativity and inventiveness in the optical and vision science research industry.

The sciences of vision have progressed a lot in recent years thanks to the numerous research works and innovations made in the materials. This new knowledge has led to significant changes in the methods of correcting vision defects, prescriptions and the development of equipment.
To help all the professionals of the eye in the daily practice of their profession, to give them access to the latest research, the MONDIAL DE L’OPTIQUE welcomes since 2010, SILMO ACADEMY, a place of progress and exchanges, a meeting of reflection of high level for the optical sector-eyewear. This area of ​​knowledge and training offers professionals who want it the information and experience they need today to understand the issues and changes in the sector.
Created in 2010 under the leadership of Guy CHARLOT, SILMO ACADEMY is composed of a Scientific Council, responsible for validating the relevance of the content of the symposia. He is the guarantor of the scientific scope of the conferences

https://en.silmoparis.com/SILMO-Signature/SILMO-d-Or-awards/SILMO-d-Or-Awards-archives/2020/Nominees-SILMO-Award

Funding Agency Comunidad de Madrid
Principal Investigator/s Eduardo Lage
Information Type of Grant: Competitive funding , Spain

Grant code: IND2019/TIC-17116

Awardee Organization: UAM / Plenoptika Europe SLU

Project Start Date: 1-Jan-2020

Project End Date: 31-December-2022

Total Funding: 148,000 Euros

MEDIC Personnel included in the grant / Role:

Dr. Eduardo Lage / IP

MsC Carlos Hernandez / PhD candidate

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AUTHORS
Ahhyun Stephanie Nam
Varshini Varadaraj
Alyssa Marie Kretz
Kanza Aziz
Marcos Rubio
Andrea Gil
Daryl Lim
Shivang R. Dave
David S Friedman
Nicholas J. Durr
Eduardo Lage
JOURNAL Investigative Ophthalmology & Visual Science June 2020, Vol.61, (ARVO 2020)
 

Purpose : A pilot study to assess the measurement of both low- and high-order ocular aberrations from a low-cost portable wavefront aberrometer.

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AUTHORS
Eduardo Lage
Frederick Armandon
Erik Makori
Martine Okello
Dan Oduo
Mary Kimani
Rolex Sang
Beatrice Macharia
JOURNAL Investigative Ophthalmology & Visual Science June 2020, Vol.61, (ARVO 2020)
 

Purpose : Although cycloplegic refraction is the gold standard for children screening, it poses significant implementation challenges when the screening is performed in schools (e.g. side effects of cycloplegia). This study aims to evaluate the performance of the QuickSee (QS) for diagnosing refractive error in children under non-cycloplegic conditions and to determine the optimal referral threshold for the device.

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AUTHORS Jesus Poderoso / Ingeniería Informática / Universidad Autónoma de Madrid
SUPERVISORS Carlos S. Hernández / MsC / PlenOptika Europe
TYPE Bachelor Thesis
ABSTRACT ABSTRACT

Refractive errors are very common eye disorders in which the eye cannot clearly focus on images. If they are not diagnosed in time, especially during childhood, they may result in severe visual impairment and even blindness. Refractive errors can be corrected simply by wearing glasses, an effective and inexpensive remedy whose cost does not exceed $5 in developing countries. Even so, refractive errors are currently one of the major global health problems. The main cause of this situation is the shortage of eye care professionals and automated equipment capable of prescribing glasses. PlenOptika proposes as a solution the QuickSee, a low cost and easy to use autorefractor. This device improves the efficiency and scope of eyecare professionals to prescribe glasses, while enabling people with minimal training in refractive techniques such as nurses, technicians or even non-healthcare personnel to carry out measurements of refractive errors quickly and reliably.

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AUTHORS
Andrea Gil
Carlos S. Hernández
Pablo Pérez-Merino
Marcos Rubio
Gonzalo Velarde
María Abellanas-Lodares
Ángeles Román-Daza
Nicolás Alejandre
Ignacio Jiménez-Alfaro
Ignacio Casares
Shivang R. Dave
Daryl Lim
Eduardo Lage
JOURNAL PLoS ONE 15(10): e0240933
ABSTRACT

ABSTRACT

Purpose
To assess the performance of an open-view binocular handheld aberrometer (QuickSee) for diagnosing refractive errors in children.

Methods
123 school-age children (9.9 ± 3.3 years) with moderate refractive error underwent autorefraction (AR) with a standard desktop device and subjective refraction (SR), with or without cycloplegia to determine their eyeglass prescription. Measurements with QuickSee (QS) were taken in 62 of these patients without cycloplegia (NC), and in 61 under cycloplegia (C). Differences in refraction values (AR vs SR vs QS) as well as the visual acuity (VA) achieved by the patients with each method (QS vs SR) were used to evaluate the performance of the device in measuring refractive error.

Results
The spherical equivalent refraction obtained by QS agreed within 0.5 D of the SR in 71% (NC) and 70% (C) of the cases. Agreement between the desktop autorefractor and SR for the same threshold was of 61% (NC) and 77% (C). VA resulting from QS refractions was equal to or better than that achieved by SR procedure in 77% (NC) and 74% (C) of the patients. Average improvement in VA with the QS refractions was of 8.6 and 13.4 optotypes for the NC and C groups respectively, while the SR procedure provided average improvements of 8.9 (NC) and 14.8 (C) optotypes.

Conclusions
The high level of agreement between QuickSee and subjective refraction together with the VA improvement achieved in both study groups using QuickSee refractions suggest that the device is a useful autorefraction tool for school-age children.

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AUTHORS
JOURNAL Special Issue “Applied Intelligent Control and Perception in Robotics and Automation”
ABSTRACT

The inspection of Personal Protective Equipment (PPE) is one of the most necessary measures when treating patients affected by infectious diseases, such as Ebola or COVID-19. Assuring the integrity of health personnel in contact with infected patients has become an important concern in developed countries. This work focuses on the study of Reinforcement Learning (RL) techniques for controlling a scanner prototype in the presence of blood traces on the PPE that could arise after contact with pathological patients. A preliminary study on the design of an agent-environment system able to simulate the required task is presented. The task has been adapted to an environment for the OpenAI Gym toolkit. The evaluation of the agent’s performance has considered the effects of different topological designs and tuning hyperparameters of the Q-Learning model-free algorithm. Results have been evaluated on the basis of average reward and timesteps per episode. The sample-average method applied to the learning rate parameter, as well as a specific epsilon decaying method worked best for the trained agents. The obtained results report promising outcomes of an inspection system able to center and magnify contaminants in the real scanner system.

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Funding Agency Comunidad de Madrid
Principal Investigator/s Eduardo Lage
Information Type of Grant: Competitive funding , Spain

Grant code:PEJD-2019-PRE/IND-15478

Awardee Organization: UAM 

Project Start Date: 1-Jul-2020

Project End Date: 30-June-2020

Total Funding: 25,000 Euros

MEDIC Personnel included in the grant / Role:

Dr. Eduardo Lage / IP

M. Eng Jesus Poderoso

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AUTHORS
Maria Tamayo
Laura Martin-Nunes
Almudena Val-Blasco
Maria Jose G.M-Piedras
Jose Alberto Navarro-Garcia
Eduardo Lage
Patricia Prieto
Gema Ruiz-Hurtado
Maria Fernandez-Velasco
Carmen Delgado
JOURNAL British Journal of Pharmacology Vol 177(14), 3273-3290
ABSTRACT
Background and Purpose

The synthetic vitamin D3 analogue paricalcitol acts as a selective activator of the vitamin D receptor (VDR). While there is evidence for cardioprotective effects of paricalcitol associated with the VDR pathway, less information is available about the structural and functional cardiac effects of paricalcitol on established heart failure (HF) and particularly its effects on associated electrophysiological or Ca2+ handling remodelling.

Experimental Approach

We used a murine model of transverse aortic constriction (TAC) to study the effect of paricalcitol on established HF. Treatment was initiated 4 weeks after surgery over five consecutive weeks, and mice were sacrificed 9 weeks after surgery. Cardiac MRI (CMRI) was performed 4 and 9 weeks after surgery. Hearts were used for biochemical and histological studies and to isolate ventricular myocytes for electrophysiological and calcium imaging studies.

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AUTHORS
Sanil Joseph
David S. Friedman
Thulasiraj Ravilla
Shivang R. Dave
Eduardo Lage
Varshini Varadaraj
Kanza Aziz
JOURNAL Investigative Ophthalmology & Visual Science June 2020, Vol.61, (ARVO 2020)
 

Purpose : In low-resource settings with large burden of uncorrected refractive errors, auto-refractors are conventionally considered too expensive and inaccurate to significantly improve refractive eye care. We compared patient acceptance of eyeglasses prescribed using a low-cost, portable auto-refractor (the QuickSee) with that of eyeglasses prescribed via standard subjective refraction. We also compared the accuracy of the QuickSee refraction measurements with subjective refraction performed by trained technicians at Aravind Eye Hospital (AEH), India.

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AUTHORS Ignacio Salinas / Ingeniería Informática / Universidad Autónoma de Madrid
SUPERVISORS Eduardo Lage / PhD / PlenOptika Europe
TYPE Bachelor Thesis
ABSTRACT ABSTRACT

This Bachelor Thesis presents the development of a calibration system for a visual simulation device: the SimVis. This system prescribes multifocal lenses allowing patients to know if they adapt correctly to their needs before surgical implantation. To approach the project, the functionality of the calibration system has been divided into three main modules: camera, communication, and image processing, which are finally integrated into a main program. In addition, a calibration cradle prototype has been built to perform verification and validation tests.

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AUTHORS / CAREER / CENTER Jaume Fabregat Marques / Ingeniería Electrónica Industrial y Automática / Universidad Carlos III de Madrid
SUPERVISORS Eduardo Lage / PhD / Universidad Autonoma de Madrid
TYPE Bachelor Thesis
ABSTRACT ABSTRACT

Motivation: Worldwide, it is estimated that more than 1 billion people do not have the eyeglasses they need. This problem is especially prevalent in developing countries due to the lack of an appropriate infrastructure for eyecare deployment and eyecare professionals capable of providing eyeglass prescriptions. The procedure for obtaining these prescriptions consist of using an objective measurement of the refractive power of the eye, which is usually very accurate but can fail in several cases, followed by a subjective refinement which is performed by an eyecare professional based on the feedback of the patient. If the initial objective measurement is not accurate, it can greatly complicate the procedure increasing the time required to refract the patient and thus the bandwidth of the eyecare professionals.

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eduardo.lage@uam.es
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