Year: 2021

AUTHORS
Andrea Gil
Carlos S. Hernandez
Stephanie Nam
Daryl Lim
Eduardo Lage
Shivang R. Dave
Conference  2022 NASA Human Research Program Investigator´s WorkShop (Online Conference)
 

INTRODUCTION

Hyperopic refractive error shift along with optic disc edema, choroidal folds, nerve fiber layer infarcts, globe flattening are referred to as spaceflight-associated neuro-ocular syndrome (SANS) [1][2]. Although the observed hyperopic shift can be corrected with eyeglasses, the time course of all these visual changes in microgravity is not well elucidated, due to the need for an accurate, precise, and easy-to-use instrument. Ophthalmic instruments that are highly repeatable such as autorefractors and optical biometers, do not meet the portability requirements for space flights [3]. Towards this need, we modified a portable handheld autorefractor (QuickSee, PlenOptika), that provides binocular objective measurements in 10 seconds, to reduce its weight and improve its form factor. This study evaluates the ability of the new prototype to accurately and repeatably assess small variations in refractive error to mimic hyperopic changes in a subject’s refractive power, and thus, its suitability as a technology for indirectly monitoring changes in axial length of the eye under microgravity conditions.

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Funding Agency Comunidad de Madrid
Principal Investigator/s Eduardo Lage
Information Type of Grant: Competitive funding , Spain

 

Grant code:IND202/TIC-17340

Awardee Organization: UAM / Plenoptika Europe SLU

Project Start Date: 1-Jan-2021

Project End Date: 31-December-2023

Total Funding: 149,000 Euros

MEDIC Personnel included in the grant / Role:

Dr. Eduardo Lage / IP

MsC Andrea Gil / PhD Candidate

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Funding Agency Translational Research Institute for Space Health-NASA
Principal Investigator/s Shivang R. Dave
Information Type of Grant: Competitive funding , United states

Grant code: NASA NNX16AO69A

Awardee Organization: Plenoptika Inc

Project Start Date: 29-November-2021

Project End Date: 29-November-2022

Total Funding: $90,000

MEDIC Personnel included in the grant / Role:

Dr. Eduardo Lage — Investigator

MsC Carlos Hernandez – Investigator

MsC Andrea Gil — Investigator

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AUTHORS
Sanil Joseph, MHA, MSc
Varshini Varadaraj, MD, MPH
Shivang R. Dave, PhD
Eduardo Lage, PhD
Daryl Lim, PhD
Kanza Aziz, MD
Sarah Dudgeon, (MPH)
Thulasiraj D. Ravilla, MBA
David S. Friedman, MD, PhD, MPH 
JOURNAL Ophthalmology
ABSTRACT

Abstract

Purpose

To compare patient preferences for eye glasses prescribed using a low-cost portable wavefront autorefractor versus standard subjective refraction.

Design

Randomized, cross-over clinical trial

Participants

Patients aged 18-40 years presenting with refractive errors to a tertiary eye hospital in Southern India.

Methods

Participants underwent subjective refraction (SR) followed by autorefraction (AR) using the monocular version of the QuickSee device. An independent optician, masked to the refraction approach, prepared eyeglasses based on each refraction approach. Participants (masked-to-refraction source) were randomly assigned to use either SR- or AR-based eyeglasses first, followed by the other pair, for a week each. At the end of each week, participants had vision checked and were interviewed about their experience with the eyeglasses.

Main outcome measures

Proportion of patients preferring eyeglasses prescribed using AR and SR

Results

The 400 participants enrolled between March 26, 2018 and August 02, 2019, had mean (SD) age of 28.4 (6.6) years and 68.8% were women. There was strong correlation between spherical equivalents using SR and AR (r=0.97, p<0.001) with a mean difference of -0.07 diopters (95% limits of agreement: -0.68 to 0.83). Of the 301 (75.2%) patients who completed both follow-up visits, 50.5% (n=152) and 49.5% (n=149) preferred glasses prescribed using SR and AR, respectively (95% CI: 45.7% – 56.3%; p=0.86). There were no differences in demographic or vision characteristics between participants with different preferences (p>0.05 for all).

Conclusions

We observed strong agreement between the prescriptions from SR and QR, and eyeglasses prescribed using SR and AR were equally preferred by patients. Wider use of prescribing based on AR alone in resource-limited settings is supported by these findings.
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During the last 25th of Febraury, the event “Learn about the best TFG of the 2019-20 academic year and how Deloitte participates in innovative and entrepreneurial projects” took place in the Autonomous University of Madrid. This time online, as a result of the current situation. Among other attendees, representing the UAM was Mr. Javier Ortega García, Vice-rector of Innovation, Transfer and Technology, who made the introduction to the event, and from Deloitte, Mr. Francisco Faraco, Partner at Deloitte – Fraud Prevention, who gave the award to the winner of the best bachelor thesis at the E.P.S. during the 2019-20 academic year, enrolled in Cybersecurity, Data Science and Artificial Intelligence categories. As it was said in the event ‘At Deloitte we reward talent and innovation with initiatives of this type’.

In this occasion the awarded was our engineer Ignacio Salinas Sánchez for his work “Development of a Calibration system for a Visual Simulation device”. The medical device was the SimVis developed by 2eyesVision: a system that prescribes multifocal lenses allowing patients to know if they adapt correctly to their needs before to surgical implantation.

The project consists not only of a software part that includes three main modules: camera, communication and image processing but also a hardware prototype with the function of carrying out verification and validation tests.

“It has been a unique opportunity and a pleasure to collaborate in the development of medical devices with the objective of helping other people, which gives you an added bonus of desire, energy and enthusiasm”, were some of Ignacio’s words.

The Jury also awarded some Special Mentions with their corresponding Diploma of Recognition to Alberto Ruiz Guijosa, Marta Simón Pinacho and Diego Sainz de Medrano Otero, for the quality of their works submitted to the contest.

In addition, during the session other topics were discussed such as Smart Stadiums, Gaming projects, “a life experience” by Álvaro Pérez (Senior Analytical Consultant at Google) and finally a success story from the entrepreneurship office of the UAM – UAM Emprende.

Thank both, Deloitte and UAM for giving us the opportunity to participate in this kind of innitiatives, where all the work, effort and time invested in these projects is recognized.

Contact Us

eduardo.lage@uam.es
+34 91 497-5787

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